Splicing and Dicing MYC-Mediated Synthetic Lethality
نویسندگان
چکیده
منابع مشابه
Splicing and dicing with a SERRATEd edge.
T he maturation and quality control of mRNA in eukaryotes is a tightly regulated, multistep process that begins on nascent transcripts. A 7-methyl guanosine (7MeG) cap structure is added to the 5 end of pre-mRNA as it emerges from the exit channel of RNA Polymerase II. The multifunctional nuclear cap-binding complex (CBC), consisting of two protein subunits (CBP80 and CBP20), assembles at the p...
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Authors: MANISHHA PATEL ([email protected]) ZONGXIANG ZHOU ([email protected]) JUN LIU ([email protected]) NICHOLAS NG ([email protected]) MINDY HSIEH ([email protected]) ANTHONY ORTH ([email protected]) JOHN WALKER ([email protected]) SERGE BATALOV ([email protected]) JENNIFER HARRIS ([email protected])
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ژورنال
عنوان ژورنال: Cancer Cell
سال: 2015
ISSN: 1535-6108
DOI: 10.1016/j.ccell.2015.09.016